average weight loss for semaglutide Tirzepatide causes more than Semaglutide Dosing for Weight Loss:

Indeed, continuous exenatide exposure once weekly elicited a greater response than did short-acting exenatide, improving glycemic and lipids controls and lipoprotein metabolism, and decreasing systemic inflammation

Doses above this level increase hepatic methionine metabolism byproducts like homocysteine, which at chronically elevated levels is associated with cardiovascular risk

You would have to take months of oral supplements to reach the blood concentration levels achieved in a single IV drip

According to the protocol by Wang et al

Folic acid antagonists: antimicrobial and immunomodulating mechanisms and applications