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Not having enough can cause tiredness, brain issues, and big red blood cells

But also different methylation processes, due to a B12-related deficiency of S-adenosylmethionine, seem to be causally involved in neuropsychiatric problems

None of the Marketing Authorisation Holders in the UK use any clinical evidence for optimal dosage of 3 monthly treatment and base the information written in their Patient Information Leaflet upon BNF Guidelines and the Martindale Drug Reference book