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According to a clinical trial published in the New England Journal of Medicine , Tesamorelin significantly reduced VAT and improved lipid profiles in patients with HIV-associated lipodystrophy (Falutz et al., 2010)

Specifically, GLP-1 use was associated with an 18% lower risk of a composite TED-related diagnosis at one year and a 10% lower risk at three years. This retrospective, population-based cohort study used the TriNetX US Collaborative Network to identify patients with thyroid disease initiating a GLP-1 drug or a non-GLP-1 active control medication

doi:10.1016/j.toxlet.2009.12.004 Tirmenstein MA, Nicholls-Grzemski FA, Zhang JG, Fariss MW (2000) Glutathione depletion and the production of reactive oxygen species in isolated hepatocyte suspensions

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