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For most users at 10001500 mg/day standardized curcumin with piperine, daily use through 12 months is supported by trials with no major safety signals

Most problems (infections, reduced potency, unexpected reactions) come from poor technique or improper storage, not from the peptides themselves

10.1073/pnas.0831128100 Boulestin A, Sandres-Saune K, Payen JL, Alric L, Dubois M, Pasquier C, Vinel JP, Pascal JP, Puel J, Izopet J: Genetic heterogeneity of the envelope 2 gene and eradication of hepatitis C virus after a second course of interferon-alpha