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Abbreviations IGF: Insulin-like growth factor CRC: Colorectal cancer IRS: Insulin receptor substrate IGFBP3: Insulin-like growth factor-binding protein 3 VEGF: Vascular endothelial growth factor HIF-1: Hypoxia-inducible factor 1 PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses PROSPERO: Prospective Register of Systematic Reviews CRPCLs: Colorectal precancerous lesions RCTs: Randomized controlled trials HNPCC: Hereditary nonpolyposis colorectal cancer FAP: Familial adenomatous polyposis CASP: Critical Appraisal Skills Programme WMD: Weighted mean difference CI: Confidence interval SD: Standard deviation IV: Inverse variance BMI: Body mass index ACF: Aberrant crypt foci EPIC: European Prospective Investigation into Cancer and Nutrition HIMS: Health In Men Study T2DM: Type 2 diabetes mellitus AGEs: Advanced glycation end products OS: Overall survival HR: Hazard ratio References Baxter RC

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The GshF was successfully expressed in the mutant strains, however, the expression levels in the mutant strains were lower than those in the control strain ZJ000 (Fig