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Vulnerable groups should be particularly focused on to ensure fair access

some countries allow its sale as a supplement, while others restrict its use to prescription medication or have banned it due to safety concerns

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Its elevation suggests changes in glutathione synthesis or utilization, although elevated urinary levels of pyroglutamic acid are often associated with glutathione depletion, some studies suggest that, under certain conditions characterized by increased oxidative stresssuch as sepsishigher urinary pyroglutamate was not correlated with worse clinical outcomes 66