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Calcitriol primarily functions by binding to the vitamin D receptor (VDR), a ligand-activated transcription factor

doi: 10.1016/S0092-8674(00)81865-6 36 FarooqiISKeoghJMYeoGSHLankEJCheethamTORahillyS

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The dimeric fraction is catalytically competent in vitro, supporting robust c-Jun polyubiquitination in the presence of Ube2d3 and neddylated CRL4, whereas stacked assemblies are consistent with an autoinhibited state