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The European Medicines Agency (EMA) is separately reviewing a Marketing Authorisation Application for apitegromab for the treatment of spinal muscular atrophy (SMA), an unrelated neuromuscular condition, with a decision anticipated in mid-to-late 2026

doi: 10.3168/jds.S0022-0302(71)85905-2 60 LaceteraNScaliaDFranciOBernabucciURonchiBNardoneA

Day 1: 100-200mg NAD IV (1-4 hrs) Day 4: 25mg NAD SQ Day 6: 25mg NAD SQ Daily: 250mg NR/NMN in the morning Week 2 We increase the SQ shots here to extend the life of the initial IV dose of NAD

Ursell et al., 2014

Patients can expect mild discomfort and swelling for 1-3 days after the procedure