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In vitro studies have examined its interaction with fibroblast and keratinocyte cell preparations, documenting that the GHK-Cu complex stimulates collagen synthesis in cultured fibroblasts independently of changes in cell number [1], and that GHK-Cu increases matrix metalloproteinase-2 (MMP-2) protein and mRNA levels in fibroblast cultures

Estrogen promotes fibroid growth by upregulating estrogen receptor alpha (ER) and stimulating growth factors (EGF, IGF-1, TGF-). Progesterone also plays a role

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