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FDA Status: Not evaluated or approved by the U.S

1991 (landmark Italian trial): A double-blind, placebo-controlled trial involving 130 patients with Alzheimer's disease demonstrated that one year of ALCAR treatment resulted in a slower rate of deterioration compared to placebo across 13 of 14 outcome measures, including significant improvements in the Blessed Dementia Scale, logical intelligence, verbal critical abilities, long-term verbal memory, and selective attention [5][17]

Gleiss A, Oberbauer R, and Heinze G (2018) An unjustified benefit: immortal time bias in the analysis of time-dependent events Transpl Int 31 (2) 125130 24