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Trophoblast-decidual cell interactions and establishment of maternal blood circulation in the parietal yolk sac placenta of the rat

The trial failed to show a significant delay of disease progression, but showed an impact on patients' Alzheimer's disease-linked proteins as well as systemic inflammation biomarkers

148 Hence, IR promotes the pathology of AD by reducing amyloid clearance and increasing tau hyperphosphorylation neurofibrillary tangles, 149 both of which are associated with cognitive impairment