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Lowering GSH further by inhibiting SLC7A11 enhanced T2 inflammatory protein expression and ferroptosis

doi: 10.1016/j.jad.2019.11.122CrossRefGoogle ScholarPubMed Bersani, G., Meco, G., Denaro, A., Liberati, D., Colletti, C., Nicolai, R., Koverech, A

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Das S, Ciombor KK, and Haraldsdottir S, et al (2020) Immune-related adverse events and immune checkpoint inhibitor efficacy in patients with gastrointestinal cancer with Food and Drug Administration-approved indications for immunotherapy Oncologist 25 (8) 669679 PMID: 31943525 PMCID: 7418359 62

In detail, elevation of HDAC6 promotes the formation of aggresome, which emerges as a cytoprotective response in the clearance of toxic misfolded protein aggregates found in neurodegenerative disease such as Parkinsons disease [90], via binding polyubiquitinated misfolded protein including CFTR-F508 [91]