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Most of the mature cathelicidins are linear peptides that adopt an -helical fold with an amphipathic character when exposed to hydrophobic environments (e.g., biological membranes), but -sheet structures stabilized by disulfide bonds, loop structures or extended polyproline structures are also known [104]

Furthermore, obese patients exhibited higher Humanin expression than those with type 2 diabetes, suggesting that obesity specifically upregulates Humanin in muscle

If the pH environment is not carefully controlled, the peptide complex can degrade or lose its intended activity over time