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Mitochondrial dysfunction is an early trigger in isoflurane-induced neuronal damage [49]

First, it was shown in vitro that treatment of astrocytes with acetyl-L-carnitine (30-100 M) induces vitagene HO-1 in a dose- and time-dependent manner and that this effect was associated with up-regulation of another vitagene HSP60 as well as high expression of the redox-sensitive transcription factor Nrf2 in the nuclear fraction of treated cells [121]

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To mitigate hypoglycemia risk, recommendations regarding initial insulin dose reduction vary based on the patients initial HbA1c level