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Insulin-like growth factor I promotes growth selectively in fetal sheep in late gestation

GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide composed of six amino acids (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) that stimulates potent growth hormone release by activating the ghrelin receptor (GHS-R1a)

In a study by Higgins et al., IGF-1 was used to treat medial femoral condylar fractures in New Zealand white rabbits

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In summary, the implication of IGF-1 in glucose and lipid metabolism and its derangements when the GH/insulin/IGF-1 axis balance fails is well documented