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It is important to distinguish between excessive supplementation and pathologically elevated B12 levels, which may indicate underlying haematological disorders, liver disease, or renal impairment rather than true overdose

Phentermine is sometimes used in combination with or as a precursor to GLP-1 therapy

Testing for MTHFR and transcobalamin mutations can show metabolic challenges

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Note: GLOW has no trial-established dose that combines the three compounds