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Results Endogenous MOTS-c levels increase upon exercise in humans To determine if endogenous MOTS-c responds to physical exertion, and thus may be involved in driving adaptation to enhance physical capacity, we collected skeletal muscle and plasma from sedentary healthy young male volunteers (24.5 3.7 years old and BMI 24.1 2.1) that exercised on a stationary bicycle (Fig

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It has also been identified as a major pathogenic driver in other organ injury-related disorders including acute kidney injury and COVID-19-induced myocarditis [3]

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