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In June 2025, the United Nations' health agency (WHO) stated that loneliness is now a global health threat, impacting one in six people worldwide

Realistic Timeline Most patients reach meaningful milestones over several months rather than weeks

Wegovy is approved for chronic weight management (2021), cardiovascular risk reduction in adults with obesity and CVD (2024), and non-cirrhotic MASH with F2-F3 fibrosis (August 2025)

Both metformin and GLP-1 RAs can induce ovulation and restore the menstrual cycle [32-35]

Be sure to document changes in a simple log or journal too, as this can help you and your clinician spot patterns, address challenges, and adjust strategies as needed