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Copper-binding tripeptide promoting skin regeneration, wound healing, and anti-aging

J Hematol Oncol 2019;12:34 30

The slight acidity of the solution (pH approximately 3.04.0 at 0.1% concentration) protonates basic amino acid residues on poorly water-soluble peptides, increasing their net positive charge and improving electrostatic interaction with the surrounding aqueous solvent a mechanism that dramatically increases the solubility of many lyophilised peptide preparations that resist dissolution in neutral or alkaline aqueous conditions

The combined actions of immune cell infiltration, pathological angiogenesis, and extracellular matrix remodeling shape the characteristic multi-zonal architecture of tophi and define their progressive nature