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The two are commonly referenced in literature with regards to tissue and cell research, both are easy to come by in terms of synthesized form for in vitro experiments, and both are often compared side-by-side with regards to structure and mechanism

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IC50 Determination Metformin was dissolved in PBS to a 20 mM concentration and filtered, while Simvastatin was dissolved in DMSO as a 1 mM working solution

Nauck M.A