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Isoform-specific binding of selenoprotein P to the -propeller domain of apolipoprotein e receptor 2 mediates selenium supply

SIRT3 has a comparatively narrower acyl pocket optimized for shorter acyl chains [72], yet it can also de-lactylate specific histone sites (e.g., H3K9 and H4K16) in defined contexts [65] and may act on nuclear substrates under stress, including lactylated proteins such as CCNE2 [73]

Lactylation modification in cardio-cerebral diseases: a state-of-the-art review

Effective treatment requires stimulating change within the dermis itself

However, important population gaps exist in the published safety data