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Fundamental questions remain regarding the future prospects of this line of drug development, including questions concerning safety and tolerability, efficacy, doseresponse relationships and therapeutic mechanisms

Taking these findings into account, along with the elevated subclinical gut inflammation and intestinal permeability observed during earlier studies involving patients with rheumatic disease, it can be proposed that gut-joint communication plays an important role in AD development (Mielants et al

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Another possible mechanism involves the drug's effects on the sympathetic nervous system the part of your body that controls stress responses which could tighten blood vessels and cut off circulation to delicate eye tissue