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Furthermore, a national cohort study found that a notable percentage of patients (up to 10%) required revisional surgery within 5 years of follow-up [16]

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Because SAM is also required for many other methylation reactions, including gene-expression regulation, high NNMT activity draws heavily on SAM and is associated in studies with reduced NAD, a coenzyme central to cellular energy production

[88] Following discussions among clinicians and people with PMOS, a majority of whom were in favour of renaming the condition, a survey was launched to find a new name