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Further research demonstrated its notable ability to lower blood sugar levels in animal experiments, including rabbits ( Jean Sterne demonstrated the effectiveness of metformin in treating diabetes in human trials for the first time ( In addition to treating T2DM, metformin modestly reduces body weight gain, which may be achieved by upregulating growth differentiation factor 15 (GDF15) ( Initial research typically viewed the liver as the main location where metformin exerts its control over glucose production, utilizing both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent pathways

and went through six human clinical trials involving over 900 participants

GLP-1 drugs like Ozempic are proving effective in a variety of applications beyond managing diabetes and weight loss

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