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This novel approach to melanocortin receptor selectivity for weight loss was informed by our previous work demonstrating that co-administration of an MC4R-selective agonist and an MC3R-selective agonist caused a greater reduction in food intake and body weight in DIO NHPs than administration of either compound alone, yielding 7.8% weight loss after 36 days (25)

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PAMAM dendrimers have NH2 terminal components, facilitating their customization to specific structures, and rendering them highly versatile dendrimers, especially in drug delivery and biological contexts

In addition, SLC7A11 inhibitors such as erastin, which induce ferroptosis, significantly improve oxaliplatin sensitivity when used in combination with FOLFOX, highlighting the potential of metabolic interventions to reverse chemoresistance [159]

This change may also be reflected in visible signs such as reduced skin vitality and uneven tone