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Pediatr Res 38:324331 Poorthuis BJ, Jille-Vlckova T, Onkenhout W (1993) Determination of acylcarnitines in urine of patients with inborn errors of metabolism using high-performance liquid chromatography after derivatization with 4-bromophenacylbromide

Daily oral L-carnosine (500 mg, p.o., daily for 3 months) significantly ameliorated the pathophysiological triad of inflammation, oxidative stress, and apoptosis in patients receiving FOLFOX-6 regimen (OXA + 5FU + leucovorin), for instance, decreasing the molondialdehyde (MDA) level (51.8%), nuclear factor-B (NF-B) (27%), and TNF- (36.6%), while increasing Nrf-2 (38.7%) ( Therefore, antioxidant drugs, including small molecular drugs, Mn-based MRI contrast agents, and natural products could alleviate, to some extent, the symptoms of PIPN