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Michael Palladinetti, global head of business development and licensing at Sanofi, told delegates attending Bio Europe Spring in Barcelona, Spain last week that history has shown us time and time again that no one has the monopoly on the next wave of innovation. Citing the recent GLP-1 wave, Palladinetti said the industry has a bit of fear of missing out (FOMO) and paid kudos to Lily and Novo for staying in the space. He added how innovation is also very difficult and that industry players need to have a broad view. Both firms are pioneers in the diabetes space, having launched their own versions of insulin over 100 years ago

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Meanwhile, cGAS-STING senses mitochondrial DNA (mtDNA) released from damaged mitochondria during ferroptosis and drives the production of type I interferons (IFN-I), thereby regulating expression of TfR1 and recruiting immune cells to intensify tissue injury (132, 133)

The CVOTs provide additional evidence for cardiovascular risk reduction with GLP-1RAs in patients with T2D