In addition, combining GLP-1R agonists with other peptide agonists or small-molecule therapeutics, including fibroblast growth factor 21 (FGF21), the farnesoid X receptor (FXR) agonist cilofexor with/without the acetyl coenzyme A carboxylase inhibitor firsocostat, a long-acting amylin agonist, cannabinoid receptor antagonists and sodium-glucose cotransporter 2 inhibitors (SGLT-2i), is currently being explored and may lead to additional improvements in NASH features vs GLP-1R agonists therapy alone [79,80,81,82,83]
Store lyophilised vials at -20C
Researchers have found that disruption of the GLP-1 receptor gene can lead to abnormal glucose tolerance in mice 4
10.1590/S1679-45082014AO2881 29 MonnoI.OguraY.XuJ.KoyaD.KitadaM
Pulmonary aspiration The American Society of Anesthesiologists (ASA) issued a press release about concerns over Ozempic and other GLP-1 RAs in June 2023