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WHO (2023)

In big systematic reviews of studies that include these and higher doses, daily intake above 200mg has often shown a decrease in efficacy that researchers call a U-shaped curve.24 That means, for the average person, taking more than 200mg could potentially work against their goals

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It is also relevant that in recent studies, we have shown that TMAO directly interacts with human platelets (both isolated and in whole blood), altering stimulus-dependent calcium signaling and promoting platelet hyperresponsiveness (4)

The honest answer is more specific