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Hypertension is the most common preventable risk factor for CVDs (including coronary heart disease, heart failure, stroke, myocardial infarction, atrial fibrillation, and peripheral artery disease), chronic kidney disease, and cognitive impairment, and also the main single factor for deaths and disability worldwide (133)

Structure-guided spike design has also been used to identify artificial substitutions in the spike sequence that can increase the expression, solubility, and stability of spike (termed HexaPro) for use as a vaccine antigen [165, 166]

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