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Its application in diabetes operates through a different pathway: it is thought to reset circadian rhythms in the hypothalamus, which regulate, among other things, daily blood glucose patterns (Shivaprasad & Kalra, 2011)
2.2 Pathogenesis and pathophysiology of hyperuricemia Hyperuricemia is the precursor state to gout, but its pathophysiological impact extends far beyond the joints, involving multiple systems, including cardiovascular diseases, chronic kidney disease, and metabolic disorders (Wang Q
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