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Neither should be self-administered or sourced outside of a medical clinic

Metametrix Institute, Duluth Zempleni J (ed) (2007) Handbook of vitamins, 4th ed

In rats subjected to experimental hypoxia, a significant stress-mediated reduction in both the rate of phosphorylated respiration (V3, a 20% decrease) and the rate of ADP phosphorylation (ADP/t, a 31% decrease) was observed in brain mitochondria

That said, women who are further past menopause can still benefit from HRT with appropriate evaluation and monitoring

He talks about it because his clinical team has used it widely for joint, tendon, and gut issues, with no reported adverse events in their patient base