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additionally, acute exercise lasting 1 h increased NAD + , NAMPT, and ATP levels in PBMCs while decreasing serum NAM levels, suggesting an increase in NAD + salvage pathway 326

Of note, neuroinflammation has furthermore been implicated in the pathophysiology of depression [87], whereas increased inflammatory markers, such as C-reactive protein (CRP) or interleukin-2 (IL-2), have been specifically described to be more associated with the atypical subtype of depression [69]

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In addition, several hormones such as cholecystokinin (CCK), GIP, and somatostatin as well as numerous neuromediators regulate GLP-1 secretion

PMC 7309364