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In practice, clinicians may consider it for weight management support in adults with overweight or obesity, particularly when lifestyle measures alone have not been sufficient

JomovaKMakovaMAlomarSYAlwaselSHNepovimovaEKucaKet al

Under hypoxia, when the flux through the tricarboxylic acid (TCA) cycle is attenuated due to HIF-1mediated inhibition of pyruvate dehydrogenase (via PDK1), glutamine becomes increasingly important for anaplerosisthe replenishment of TCA cycle intermediates necessary for the synthesis of macromolecules (79, 90)