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Colorimetric assay of MDA and GSH in hepatic tissue homogenate Oxidative stress was evaluated by assaying reduced glutathione (GSH) and malondialdehyde (MDA) content in hepatic tissue homogenates using colorimetric kits (Biodiagnostic, Egypt) and following the instructions of the manufacturer

Semaglutide is a long-acting GLP-1 receptor agonist that mimics the action of incretin hormones

Compounded medications discussed are prepared by licensed pharmacies registered with FDA as facilities, but the compounded products themselves are not FDA-approved and have not undergone FDA evaluation for safety, efficacy, or quality

Unlike other weight-loss agents, the reductions in weight with semaglutide were clinically significant in terms of the patients perception of their well-being and the reduction of cardiovascular risk

however, this difference was not observed under chow-fed condition (Supplemental Figure 7A)