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Therefore, our finding that SFN has an immunosuppressive effect on untransformed human T-cells may explain why treatment with SFN did not lead to amelioration of cancer severity in patients as demonstrated in a number of clinical trials ( in vitro experiments on tumor cells such as breast cancer cell and hepatocellular carcinoma cell strongly suggested that SFN has anti-tumor properties (63)

Acknowledgements The present study was supported by the Research Council of Norway [grant number: 214329]

When Pickart and colleagues first characterized the compound from albumin fractions in human plasma, they noted that its copper-binding behavior differed from simple copper salts in cell culture assays