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The liver is the principal site where cholecalciferol is converted to 25(OH)VD by VD-25-hydroxylase (cytochrome p450 enzymes [CYP], CYP2R1, CYP27A1 ) (9, 14, 45, 56)

Dihydroartemisinin can induce ferroptosis in PDAC cells, and dihydroartemisinin combined with cisplatin can cause catastrophic accumulation of free iron and mitochondria-derived ROS in PDAC cells and lipid peroxidation, and impaired mitochondrial homeostasis, 187 indicating ferroptosis can increase the cytotoxicity of cisplatin to PDAC cells and overcome PDAC cisplatin resistance

Read the full article here: #Orthopedics #SportsMedicine #RegenerativeMedicine #EvidenceBasedMedicine #BPC157 #SmartMedicine #followthefro Thanks for putting this together, Dr

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We're talking about a nuanced decision, one that reflects a deep understanding of pharmacokinetics and research design