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Glucagon-like Peptide-1 Receptor Agonists and Ischaemic Heart Disease Ischaemic heart disease is a major risk factor for HF (both HFrEF and HFpEF)

These receptors, including B-cell lymphoma 2/adenovirus E1B 19-kDa-interacting protein 3 (BNIP3), BNIP3-like (BNIP3L), FUN14 domain-containing protein 1 (FUNDC1) and the activating molecule in BECN1-regulated autophagy protein 1 (AMBRA1), would bind with LC3 to form autophagosome (Dagar et al., 2022)

Semaglutide produced 14.9 percent body weight loss over 68 weeks in the STEP 1 trial

these have not been systematically characterized