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Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study Nature Medicine 2019;25:1096-1103
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A qualified healthcare provider should establish baseline symptoms (bowel habits, reflux, abdominal pain), review medications that interact with bile (e.g., fat-soluble vitamins, certain antibiotics), and schedule follow-up assessments at 2-4 weeks post-initiation
Finding the human and porcine peptide to have identical sequences, the team concluded 'GLP-1 (PG 78-107 amide) from the small intestine seems to be a new hormone with important functions in the control of metabolism and glucose turnover' (rskov, Bersani, Johnson)