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The clinical potential of this approach is underscored by the approval of istradefylline in Japan and the United States as an adjunct therapy for PD patients experiencing motor fluctuations, representing the most advanced A 2A receptor antagonists in clinical development [480482]

The article's main point is that no safety data exist for the interaction, so the combination adds complexity without a clear benefit to weigh against it

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Efficacy and safety of vandetanib in progressive and symptomatic medullary thyroid cancer post hoc analysis from the ZETA trial

While weight loss is likely to benefit these patients, GLP-1 also modulates heart function