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M1 macrophages play a key role in the initial stages of the inflammatory response by releasing considerable amounts of inflammatory agents such as tumor necrosis factor (TNF-), IL-6 and IL-12, which contribute to aggravating inflammation

IVF outcomes vary by disease stage: while less advanced stages show success rates similar to other infertility causes, advanced stages are associated with lower fertilization, implantation, and clinical pregnancy rates

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Mitochondria have emerged as dynamic signalling organelles that regulate cellular function beyond their metabolic roles 54

doi: 10.1016/0968-0004(90)90206-q