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Integrated metabolomics and proteomics platforms revealed a marked increase in fatty acid oxidation-related metabolites, as well as proteome changes, in PDAC treated with GLS1 inhibitors, suggesting that treatments should target multiple metabolic pathways to overcome metabolic plasticity 112,113

reported that -GalCer treatment activates NKT cells to promote liver regeneration via the TNF and Fas/Fas ligand-mediated pathways

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ASAs reduction of fatigue symptoms may be through the drugs antipyretic effects [176, 177], which is supported by a recent study that found a correlation between fatigue, as measured by FSS and MFIS, and elevated body temperature in RRMS patients [164]

Individual Considerations Factors such as body weight, metabolic rate, and overall health will influence the optimal dosage for each individual