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CHMP opinion adopted 18 May 2017

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[6] [8] Estradiol cypionate is contraindicated during pregnancy because exogenous estrogen has no therapeutic role in gestation and in utero exposure could theoretically disturb fetal endocrine development or contribute to structural anomalies, although robust human teratogenicity data are limited

These shifts are highly context-dependent and vary by soil type, plant species, and management practices