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Variant CJD is acquired by ingestion of meat from cattle afflicted by bovine spongiform encephalopathy, with the BSE prion crossing the species barrier and misfolding native human brain PrP c

GSH behaves as redox sensor at the DNA synthesis onset by maintaining nuclear architecture providing the appropriate redox environment for DNA replication and safeguarding DNA integrity (72) and is a key regulator of epigenetic events critical in cell proliferation regulation and cellular resistance to apoptosis (73)

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however, including a control tube can mitigate this effect

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