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This work was supported by the National Natural Science Foundation of China (32371255 and 32071203 to LHZ, 32130022 and 82121005 to HEX, 82404881 to QNY)

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The permeability of the non-targeted nanocarriers was similar in the BBB models with control (3-PLG-dopa P app : 5.73 10 6 cm/s) or PD organoids (3-PLG-dopa P app : 5.65 10 6 cm/s) in the acceptor compartment (Fig

Tesamorelin's half-life falls between Sermorelin and CJC-1295, typically around 26-38 minutes