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J.HsiehM

We focused on genes involved in key energy-expending pathways, including fatty acid oxidation ( Cpt1b, Lpl, Acadm, Acadl ), thermogenesis ( Ucp1, Ucp3, Pgc1a, Dio2 ), basal energy metabolism ( Sdhb, Pfkm ), and energy-wasting futile cycles ( Alpl, mCBK, Serca2a, Serca2b )

Ethics statement All animal experiments were conducted in accordance with applicable laws and institutional guidelines, approved by the Institutional Animal Care and Use Committee (IACUC) of the University of Brain Education

For example, during structural LTP (sLTP) induced by the glutamate uncaging at single spines of cultured hippocampal neurons, RhoA and Cdc42 activity was transiently increased and then decayed to a slight but stable elevation, coinciding with spine volume enlargement during sLTP (Murakoshi et al., 2011)

Phase 3 trials are underway with potential approval in 2027