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Recent comprehensive studies have also demonstrated the favorable impact of GLP-1 RAs on cardiovascular wellbeing

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Direct mechanisms may involve GLP-1 receptor activation on vascular endothelial cells, whilst indirect effects result from weight loss, improved glycaemic control, and reduced visceral adiposity, all of which independently lower inflammatory burden

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2 However, since GLP-1 is easily degraded within a few minutes by dipeptidyl peptidase 4 (DPP-4), the GLP-1 receptor agonist such as Exenatide and Liraglutide are used to prolong this effect