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Chronic kidney disease affects 37 million Americans, with stages 1-2 showing minimal symptoms while stages 4-5 require dialysis preparation as kidney function drops below 30%
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No significant difference in the prevalence of symptoms was found between participants with MMA levels 400 nmol/l (n = 60) and those whose levels were 600 nmol/l showed some improvement in neurological symptoms (Hvas, 2001b)
Among the enriched pathways, Neuroactive ligand-receptor interaction and Calcium signaling pathway were prominently represented across all groups
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