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Patients with kidney disease can typically use semaglutide without dose adjustment, but should be monitored for dehydration which could worsen kidney function

Benztropine, biperiden, diphenhydramine, ethopropazine, orphenadrine, procyclidine, and trihexyphenidyl are included in this therapeutic class of drugs, though there is little pharmacokinetic information available on them because of their low plasma drug concentrations [55,57]

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People who have difficulty absorbing vitamin B12, such as those with Crohns disease, may benefit from B12 injections which avoid the need for absorption in the digestive tract