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Remethylation requires folate and B12 coenzymes while transsulfuration requires pyridoxal-5-phosphate, the B6 coenzyme

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It is considered only for the severe, refractory end of the disease

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In protocol 2, subjects were ran- domized to receive UV-B exposure on the buttock at either the start of MT-1 treatment (group A) or immediately after finish- ing the 10-day course of MT-1 (group B)